By B. Innostian. University of Science and Arts of Oklahoma. 2018.

Physiological Action—Near the point of the administration of a hypodermic injection of the alkaloid buy strattera 40mg overnight delivery, a few drops of sweat appear within from four to six minutes after the injection cheap 10mg strattera, to be immediately followed with moisture on the forehead purchase 10mg strattera amex, neck and chest, and in quick succession the entire body is bathed with a most profuse perspiration. Ellingwood’s American Materia Medica, Therapeutics and Pharmacognosy - Page 337 It is a powerful anti-diphtheritic and sialogogue, acting profoundly as a stimulant upon the secretions of the entire glandular system. No one known remedy stimulates every secretion of the body simultaneously as profoundly as does this agent. The depression of the agent should not be allowed to progress; after the sweating has continued a few minutes profusely, a little whisky, brandy, tincture of ginger, or tincture of capsicum should be given in hot water, and occasionally repeated while the transpiration progresses. If the heart shows the influence of the depression, a hypodermic of strychnine may be given, or a few drops of the tincture of cactus, strophanthus, digitalis, or nux vomica. If it is desirable to stop the sweating abruptly, atropine hypodermically may be resorted to. The extreme effects of the agent need not be obtained in many cases, but owing to the susceptibility of some cases a small dose will sometimes produce extreme results. Most observers state that it is best to quench the thirst with weak coffee or milk and not with-cold water. It is undesirable that the patient swallow the saliva when the agent is administered after the bite of venomous snakes or in threatened hydrophobia or if given as an antidote to poisons. When the agent fails to act upon the skin it often expends its force upon the salivary glands, kidneys, stomach, intestines or lungs, producing extreme secretion or excretion from these organs. In some cases this agent produces nausea, vomiting, diarrhea, contracted pupil, extreme weakness, dimness of vision, sighing respiration, palpitation and collapse; but these symptoms of alarming nervous depression rarely occur and are easily combated with atropine. Specific Symptomatology—The direct indications for this agent are acute suppression of the secretions, especially of those of the skin in sthenic conditions usually with distress, elevation of temperature, sharp, hard pulse, dry skin, dry mucous membranes, constipation, and small quantity of urine with dark color and high specific gravity. Kinnett gives the specific indications for its use, as dry hot skin, dry parched mouth, pulse full and very strong, patient restless and uneasy, Ellingwood’s American Materia Medica, Therapeutics and Pharmacognosy - Page 338 suppression of the secretions, especially of the kidneys, which seem to be unable to act properly. His contra-indications are feebleness, weak pulse, weak heart action, tendency to depression. Contra-Indication—Jaborandi should be avoided in asthenic conditions, or where there is feeble or dilated heart, and used with care in old people and-young children. Except in its influence on laryngeal and bronchial disorders, and in the sthenic stage of diphtheria when it loosens the membranes. Therapy—At the onset of acute febrile and inflammatory conditions, especially if there be rigors, hot, full head, and a bounding, hard pulse, a foot bath of hot water and a full dose of jaborandi with proper supportive treatment subsequently will often end the attack abruptly. The stage following the influence of the agent if the temperature has subsided, has all the conditions in which quinine works to its best possible advantage. Several recent writers have written enthusiastically on the action of jaborandi or pilocarpine in establishing a favorable crisis early in the severe forms of acute disease. Pernicious malarial fever, typho-malarial fever, inflammatory rheumatism, and other of the severer forms of inflammatory disease they claim may be aborted by the use of full doses of this remedy. Where jaborandi can be administered by the mouth, it is preferable, although some claim that pilocarpine hypodermically invariably produces better results. A number advise the use of this remedy in comatose, delirious and colliquative forms of pernicious intermittent fever. These writers agree upon the surprising influence of the remedy, where at the onset of this disease or of other acute specific fever there is great excitable mania— extreme violent delirium, which in its seriousness overtops all other conditions. If an eighth of a grain of pilocarpine be administered hypodermically, the delirium disappears at once, quiet and restfulness obtain without the occurrence of the physiological action of the remedy upon the skin or salivary glands. There is a disagreement of opinion as to its value in the treatment of convulsions. Kinnett claims that where the intestinal tract is overloaded with irritating material, it produces both emesis and active free bowel movement, at the same time stimulating the action of the kidneys and skin. In a case of extreme malarial poisoning, in a strong man, the bowels had Ellingwood’s American Materia Medica, Therapeutics and Pharmacognosy - Page 339 not been moved for three days, nor the urine voided for eighteen hours. The skin was of a jaundiced appearance and the conjunctivae was distinctly yellow. One-half grain of pilocarpine hypodermically, caused salivation in three minutes, perspiration stood on the neck and forehead in great drops, the face and skin became extremely red at first and pale as the perspiration advanced. The doctor claimed that more was accomplished by this one dose of medicine in one hour in the way of elimination, than he could have accomplished otherwise, in forty-eight hours. The tense red, bloated countenance, the bleared congested eyes, the general repulsive facial aspect pass away, and the skin assumes a clean and soft appearance, the features are calm, and the eyes clear. It has been used with good advantage in the treatment of gall stones, one-eighth of a grain three or four times a day has relieved severe cases. In inflammations, of the lungs or pleura, with exudation, it promotes resolution and quickly removes the exudate. In bronchitis with dry, irritable, or hoarse cough, with imperfect secretion, it acts admirably as an expectorant.

Marines at Camp Pendleton were treated for 208 Jimson Weed hallucinations from recreational jimson weed usage cheap strattera 10 mg without a prescription. A few years earlier a sur- vey of drug users in the South African military found about 3% to be using jimson weed buy 25mg strattera with visa. Some jimson weed users describe sensations of flying buy strattera 10mg mastercard, instant travel between one city and another, and communication with plants and inanimate objects. Although insects are a commonly reported visual hallucination from jimson weed, one uncommon sensation is a feeling of crawling insects, reminiscent of the “coke bugs” hallucination associated with cocaine. In keeping with an old but largely abandoned tradition of medicine, an articulate medical journal author engaged in Datura self- experimentation and produced a graphic account of interactions with charms of nineteenth-century Paris and with horrors of twentieth-century monsters. A witness later “told me that I fought the restraining devices so violently that he thought every blood vessel in my face and neck would explode. The Ames test, a standard laboratory procedure that screens sub- stances for carcinogenicity, indicates jimson weed seeds have potential for causing cancer. Birth defects did not become more common in children of 450 pregnant women who received the atropine component of jimson weed. The same lack of effect on congenital abnormalities was observed in a similar number of pregnancies after the women used the scopolamine component of jimson weed, a finding consistent with a rodent study. Jimson weed is botanically classified as the stra- monium species of the Datura genus. Other Datura genus plants around the world are used for similar effects, but they are not jimson weed. Johnson, “Mystical Force of the Nightshade,” International Journal of Neuro- psychiatry 3 (1967): 272. The substance was invented in the 1960s and was used as an anesthetic for Vietnam War combat casualties; it has been routinely used for war injuries ever since. Third World physicians report the drug is safe for surgical use outside high-tech environments. Ketamine is also a veterinary anesthesia drug used with wild animals ranging from giraffes and gazelles to polar bears and arctic foxes. Two researchers reported that ketamine therapy with 42 alcoholics produced a two-year abstinence from drinking in 15 of them, an outstanding result. Other researchers report one-year abstinence in almost 66% of 111 al- coholics who received ketamine therapy (perhaps a single dose), as opposed to 24% in 100 who did not receive ketamine. Among the 111 in the original group, 81 were tracked for two years, and 40% of the 81 remained abstinent. Admittedly they are related to self-insights Ketamine 211 prompted by the substance and guided by psychotherapists, but in principle a single dose of a drug is unlikely to stop addiction to some other drug. Experiments indicate ketamine may have potential for treating migraine headache and depression, and researchers have seen evidence that ketamine may improve asthma and shrink breast cancer cells. Ketamine can reduce phantom limb pain, a strange affliction in which a person senses that an am- putated limb is still present and hurting. The drug has been used in psycho- therapy to help persons face and deal with unpleasant memories, a process accompanied by what researchers described as “mind expanding effects. Researchers have described such effects as “profound” among alcoholics, and illicit ketamine users have said such effects are “intense. Users may feel like their bodies are transforming into harder or softer substances. Some users take the drug to enter the “K-hole,” a semiparalytic state described as similar to near-death experiences in which people perceive their conscious- ness as floating above their bodies, sometimes accompanied by meaningful hallucinations and by insights about the user’s life and its proper place in the cosmos. Examination of deaths among recreational ketamine users in New York City in a two-year period during the 1990s found none in which ketamine was the only substance in the person’s body. Children have accidentally been given 5 to 100 times the normal size dose and have survived with no apparent injury. Nausea and vomiting have been reported, and scientific literature contains several mentions of temporary breathing interruption caused by the drug. Increased pressure within the eye (a potential problem for glaucoma sufferers) has been measured following a ketamine dose, but not all research- ers looking for that effect have found it. The drug can interfere with a male’s physical ability to engage in sexual activity. Experiments show that ketamine can cause brain damage in rats and that simultaneous use of nitrous oxide worsens the damaging action. Ketamine can cause nervous agitation, extra salivation, blood pressure elevation, abnormal heartbeat, and muscle injury. Persons suffering from the body chemistry disorder porphyria should exercise caution about ketamine use. Tests indicate ke- tamine can alter visual perception for at least 24 hours, causing people to misjudge size and speed of objects (implying that driving skills may be im- paired). Long-term use may cause persistent difficulties with attention, mem- ory, and learning ability. The substance can create amnesia about what happens while a person is under the drug’s influence. Ketamine’s psychological actions have been characterized as similar to tem- porary schizophrenia.

Higher doses may cause hair loss cheap strattera 40mg visa, greasy skin and hair 25 mg strattera fast delivery, and possibly breakouts with cystic acne buy 10 mg strattera free shipping. Some chiropractors and naturopathic physicians hand out glandular supplements like candy, claiming that dried pulverized adrenal and pituitary glands of animals can adjust cortisol levels. But searching the medical literature going back to the 1950s, and reviewing the findings of Hans Selye, who popularized modern stress research, I could find no rigorous data in humans to support this practice. Although many of my clients swear by their glandulars, I do not feel we have sufficient evidence or safety data to prescribe glandulars for high cortisol. Treatment protocol: I self- prescribed a softgel of fish oil (4,000 mg/day), phosphatidylserine (400 mg/day), and rhodiola. Although my salivary cortisol started to come closer to the normal range, it remained high in the morning, especially with consumption of caffeine. So I gave up caffeine and joined a meditation group to provide more structure and accountability. As I became more comfortable with meditation, I noticed that a key feature of stress- crazed overwhelm is that it robs me of discernment. In other words, when I was overwhelmed, my external circumstances did not change, but it felt like they did. It felt to me as if my husband was more critical and annoying, my kids, more demanding. I learned that I find the correct dose of meditation to get to insight; twenty minutes is my sweet spot. Even though it often feels as though the stressors are external, with time and wisdom I’ve determined that the locus of control is internal when it comes to stress response. I try to choose how I respond to stressors rather than going into amygdala hijack. I’ve learned that contemplative practice is a nonnegotiable aspect to my day: it has improved my attention, made me more mindful of what I eat— which helped lead to a 25- pound weight loss—and given me a deeper sense of real choice during my day. I am more patient with my kids, better organized, happy in my work, and more joyful overall. Yes, I still lose my cool, but I’ve become far more skillful at what was clearly my Achilles’ heel: high cortisol and the roller- coaster ride it can take you on. I understood what William James meant by “The greatest discovery of any generation is that a human can alter his life by altering his attitude. I taught myself how to uplevel and downlevel my nervous system more consciously and expertly. Part B: The Gottfried Protocol for Low Cortisol As mentioned in The Gottfried Protocol for High Cortisol, the following solutions are for informational and educational purposes only. Start first with the lifestyle resets, and consult a physician about the advisability of applying further approaches to your symptoms or medical condition, particularly herbal therapies such as licorice, which may cause blood pressure to rise excessively. Step 1: Targeted Lifestyle Changes and Nutraceuticals Get some exercise, perhaps African dance. A fascinating study of college students compared mood and cortisol levels before and after they attended one of three ninety- minute classes: yoga, African dance, or a biology lecture. African dance raised cortisol and mood, yoga lowered cortisol and raised mood, and the lecture changed neither mood nor cortisol. Before I began medical school, I was a bioengineer, and my best friend, who happened to be a rocket scientist, was a remarkably calm woman who never seemed to get stressed out like me. She had a great way of approaching problems, which I call the modular approach: she would take a problem and, rather than trying to solve the whole gigantic hairy thing at once, break it down into component parts, or modules. The interesting backstory to adrenal healing is that much of the research on antistress effects of nutrients and herbs was conducted by Soviet researchers in the 1970s (and are published in Russian). One study showed that a combination of vitamin C (200mg three times per day) plus an intravenous combination of vitamins B1 and B6 restored cortisol production and diurnal rhythm. Step 2: Herbal Therapy Botanical therapies that are proven to raise cortisol include the following: Licorice (Glycyrrhiza). One study of children of women who consumed varying amounts of licorice found that the more licorice the moms consumed, the higher the children’s cortisol levels. Consider deglycyrrhizinated licorice, a capsule or chewable tablet with the chemical bits removed that raise blood pressure. I generally recommend that people with low cortisol try a small dose of root extract: 600 mg, standardized to 25 percent (150 mg) glycyrrhizic acid—and check their blood pressure with a home device and at their local doctor’s office. In patients with Addison’s disease, licorice and grapefruit juice have been shown to raise cortisol levels. In one study, licorice raised median cortisol serum levels and urinary cortisol, whereas grapefruit juice significantly raised serum cortisol. This makes me nervous because any adrenal support should be given extremely cautiously and with an entire whole-foods and lifestyle adjustment for sustained results. In other words, you need the foundation of nutrient-dense whole foods (not processed foods, and especially not refined carbohydrates, which worsen adrenal problems), restorative sleep, and supplements to fill nutritional gaps before resorting to a quick-fix prescription pill. Furthermore, if you take external cortisol for more than a few months, you could develop secondary adrenal insufficiency. If you still suffer with the symptoms listed in the questionnaire despite trying Step 1 and Step 2 of The Gottfried Protocol (pages 116–118), I strongly encourage you to ask your doctor to test your cortisol.