{"id":30175,"date":"2019-02-07T09:11:00","date_gmt":"2019-02-07T13:41:00","guid":{"rendered":"https:\/\/seryhumano.com\/web\/?p=30175"},"modified":"2019-02-07T09:11:38","modified_gmt":"2019-02-07T13:41:38","slug":"desarrollan-una-barrera-hematoencefalica-artificial","status":"publish","type":"post","link":"https:\/\/seryhumano.com\/web\/?p=30175","title":{"rendered":"Desarrollan una barrera hematoencef\u00e1lica artificial"},"content":{"rendered":"\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"779\" src=\"https:\/\/seryhumano.com\/web\/wp-content\/uploads\/2019\/02\/barrera-hematoencef\u00e1lica-1024x779.jpg\" alt=\"\" class=\"wp-image-30176\" srcset=\"https:\/\/seryhumano.com\/web\/wp-content\/uploads\/2019\/02\/barrera-hematoencef\u00e1lica.jpg 1024w, https:\/\/seryhumano.com\/web\/wp-content\/uploads\/2019\/02\/barrera-hematoencef\u00e1lica-300x228.jpg 300w, https:\/\/seryhumano.com\/web\/wp-content\/uploads\/2019\/02\/barrera-hematoencef\u00e1lica-768x584.jpg 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>La barrera hematoencef\u00e1lica\nconstituye un mecanismo de protecci\u00f3n esencial del cerebro. Evita,\nprimordialmente, que los agentes pat\u00f3genos o t\u00f3xicos de la sangre se filtren a\ntrav\u00e9s del tejido cerebral. Pero, por otro lado, supone un muro infranqueable\npara muchos medicamentos que podr\u00edan ayudar a tratar enfermedades neurol\u00f3gicas.\nCon el fin de realizar mejores pron\u00f3sticos acerca de qu\u00e9 sustancias activas\nlogran alcanzar el cerebro, el equipo dirigido por Choi-Fong Cho, de la Escuela\nde Medicina de Harvard, ha construido un modelo que sigue los principios de la\nbarrera hematoencef\u00e1lica.<\/p>\n\n\n\n<p>En los organismos vivos, las\nc\u00e9lulas endoteliales de los vasos sangu\u00edneos se hallan impermeabilizadas mediante\nel cierre que configuran los estrechos contactos celulares. En el modelo de\nCho, los esferoides (aglomeraciones esf\u00e9ricas de c\u00e9lulas endoteliales,\nastrocitos y pericitos que se obtienen de simples cultivos celulares)\ndesempe\u00f1an el papel de las paredes de los vasos sangu\u00edneos. En condiciones\ndeterminadas, estos esferoides se agrupan autom\u00e1ticamente y forman barreras\nhematoencef\u00e1licas. Tambi\u00e9n se asemejan en la permeabilidad bioqu\u00edmica, puesto\nque en el interior de los esferoides se acumulan sobre todo aquellas sustancias\nconocidas que pasan sin problemas de la sangre al cerebro.<\/p>\n\n\n\n<p>En comparaci\u00f3n con otros\nmodelos, los esferoides facilitan una mejor predicci\u00f3n sobre la capacidad de\nuna sustancia para atravesar la barrera hematoencef\u00e1lica. Los investigadores\nesperan que su modelo ayude a encontrar procedimientos para abrir de manera\nintencionada la barrera hematoencef\u00e1lica.<\/p>\n\n\n\n<p>seryhumano.com \/ <a href=\"https:\/\/twitter.com\/kiklikian\">Dr. Juan Kiklikian*<\/a><\/p>\n\n\n\n<p>Neurocirujano \/ Neuroendoscopista<\/p>\n\n\n\n<p>Con informaci\u00f3n de Nature Communications<\/p>\n","protected":false},"excerpt":{"rendered":"<p>La barrera hematoencef\u00e1lica constituye un mecanismo de protecci\u00f3n esencial del cerebro. Evita, primordialmente, que los agentes pat\u00f3genos o t\u00f3xicos de la sangre se filtren a trav\u00e9s del tejido cerebral. Pero, por otro lado, supone un muro infranqueable para muchos medicamentos que podr\u00edan ayudar a tratar enfermedades neurol\u00f3gicas. Con el fin de realizar mejores pron\u00f3sticos acerca&hellip;<\/p>\n","protected":false},"author":306,"featured_media":30176,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[120],"tags":[5437,1828],"class_list":["post-30175","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ser-saludable","tag-drjuan","tag-neurologia","category-120","description-off"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Desarrollan una barrera hematoencef\u00e1lica artificial &#187; SeryHumano.com<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/seryhumano.com\/web\/?p=30175\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Desarrollan una barrera hematoencef\u00e1lica artificial &#187; SeryHumano.com\" \/>\n<meta property=\"og:description\" content=\"La barrera hematoencef\u00e1lica constituye un mecanismo de protecci\u00f3n esencial del cerebro. Evita, primordialmente, que los agentes pat\u00f3genos o t\u00f3xicos de la sangre se filtren a trav\u00e9s del tejido cerebral. Pero, por otro lado, supone un muro infranqueable para muchos medicamentos que podr\u00edan ayudar a tratar enfermedades neurol\u00f3gicas. Con el fin de realizar mejores pron\u00f3sticos acerca&hellip;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/seryhumano.com\/web\/?p=30175\" \/>\n<meta property=\"og:site_name\" content=\"SeryHumano.com\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/seryhumano\/\" \/>\n<meta property=\"article:published_time\" content=\"2019-02-07T13:41:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2019-02-07T13:41:38+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/seryhumano.com\/web\/wp-content\/uploads\/2019\/02\/barrera-hematoencef\u00e1lica.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"779\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Juan E. 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